Updating the sequence based classification of glycosyl hydrolases speed dating in poole and bournemouth
Further, this flood of data will cause an increasing reliance on computer-based annotation, which necessarily requires a robust framework to produce meaningful functional predictions.
The division of CAZyme families into subfamilies based on phylogenetic analysis has been applied as a successful approach to meet this challenge: Subfamily classification of GH13, GH30 and all of the PL families has demonstrated that the majority of the defined subfamilies were monospecific, thus indicating a significantly better correlation of substrate specificity between sequences at the subfamily level than the family level .
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Glycoside hydrolases are enzymes that catalyze the hydrolysis of the glycosidic linkage of glycosides, leading to the formation of a sugar hemiacetal or hemiketal and the corresponding free aglycon.
Glycoside hydrolases are also referred to as glycosidases, and sometimes also as glycosyl hydrolases.
Within the large GH5 family, a discernible diversity of sequences was observed soon after its creation.
The first five subfamilies of GH5 (A1-A5) were identified as early as 1990 [ that arise from a common but very distant ancestor; despite weak sequence similarity, clan members share conserved protein fold and catalytic machinery).